Production Of A Highly Concentrated Monoclonal Antibody

By Sandeep Kristiansson

The subcutaneous (SC) delivery of monoclonal antibodies (mAbs) offers advantages over intravenous (IV) infusion, for it is less invasive, reduces administration time, and enables self-administration. However, to meet the required dosage within the limited volume of SC administration, formulations often need to be highly concentrated. Often, formulations exceed 100 g/L and have the potential to reach over 200 g/L. Discover how you can achieve a final mAb concentration above 200 g/L while maintaining critical quality attributes.