Product/Service

Pre Formulation Services

Source: UPM Pharmaceuticals

UPM Pharmaceuticals can perform investigations of the physical and chemical properties of an API alone or in combination with other drug substances or exipients. These studies provide valuable data and information so our experienced formulators can develop the most stable and bioavailable dosage forms. The formulations that UPM develops for its clients can be scaled up for clinical and ultimately commercial supply.

UPM’s Preformulation capabilities:                                          

  • Particle Size Analysis(by laser)
  • Differential Scanning Calorimetry(DSC)
  • Thermal Gravimetric Analysis(TGA)
  • Osmolality
  • Coulometric Moisture Analysis
  • HPLC with ELSD
  • Dynamic Moisture Sorption
  • Moisture Sorption Isotherm
  • Surface Tension
  • Heat of Solution
  • Ph/PKa
  • Flame Photometry
  • Solubility
  • Microscopy
  • Equilibrium Solubility in Various Solvents
  • Exipient Interactions / Compatibility
  • Melting Point
  • Glass Transition
  • Decomposition
  • Purity Analysis
  • Crystallinity
  • Polymorphism
  • Stability

UPM’s key Pre-Formulation equipment includes:

  • Thermogravimetric Analyzer
  • Differential Scanning Calorimetry
  • Particle Size Analyzer by Laser
  • FT-IR
  • Static Humidity Chambers
  • R&D Stability Chambers
  • Flodex
  • Bulk/Tap Density
  • Sonic Sifter
  • Powder Dispenser

Key advantages to working with UPM’s team:

  • Extensive equipment train to carry out essential testing
  • Comfortable with API sparing techniques
  • Experience in method development and transfer techniques
  • Dedicated team of analysts, formulators, and manufacturing associates who will work closely together from early stage development to GMP scale up
  • Peer-to-peer communication on a consistent basis
  • On site scale up for clinical and commercial supply
  • Data and client confidentiality from relationship on set