Overcome CRISPR's Limitations With TARGATT™ Gene Knock-In Technology

CRISPR has undeniably transformed the life sciences, but it is not the optimal tool for every gene editing application. Its reliance on host DNA repair mechanisms, low knock-in efficiency for DNA fragments larger than 3–5 kb, and the potential for off-target effects due to double-strand breaks can make it challenging and time-consuming for certain projects.

As a company committed to advancing allogeneic cell therapies, we recognized the need for a safer, more efficient method to insert DNA into mammalian cells. This need led us to develop TARGATT™ gene knock-in technology — a precise, reliable alternative designed to overcome the limitations of traditional CRISPR-based approaches.