Nanomilling For Better Solubility And Improved Bioavailability

Bioavailability, a vital aspect of drug development, refers to a drug's capacity to be absorbed and utilized by the body. To achieve bioavailability, a drug must be soluble, particularly in water. Numerous currently available drugs exhibit poor water solubility, prompting opportunities for patent extensions or 505(b)(2) new patents through formulation enhancements facilitated by nanomilling.

Nanomilling, applicable to APIs with water solubility below 200 µg/mL, is a versatile drug delivery method suitable for oral, injectable, inhalable, and buccal applications. It involves mechanically breaking down coarse particles to enhance drug particulates in formulations, impacting dissolution rate and bioavailability. This universal technique has broad commercial and industrial applications, offering adaptability to both aqueous and non-aqueous soluble drugs.

However, namomilling demands specialized CDMO expertise, gained through broad API development experience. Explore how Altasciences experts, equipped with state-of-the-art facilities like the Netzsch DeltaVita 15-300 mill, handle formulations to commercialization, utilizing wet milling to reduce particles to nanometer size, fill vials (0.3 ml to 500 ml), and provide comprehensive packaging solutions.