Mitigate Risk By Conducting Filling Assessments During Formulation Development

Prior to coming to Experic, the client had invested a great deal of time developing a gravimetric filler that used a vibratory filling mechanism. Unsurprisingly, they found that their blended formulation segregated at certain parameter settings and they could only achieve, at best, a 70% yield of finished product.

Due to this experience, Experic recommended conducting a formulation filling feasibility study to gain the valuable information needed for the client to decide the course of action for future development of the product.

Experic also suggested a drum filling strategy since it is capable of handling cohesive powders without using vibration, which can lead to formulation segregation. Additionally, drum filling is a volumetric process which is generally favored over gravimetric filling for small doses due to its scalability. The Drum Lab was specifically selected because it does not require much formulation for each experiment and can be quickly cleaned and reassembled to increase the experimental throughput.