Microbial Tech Transfer: Tips To Consider When Selecting A CDMO

When selecting a CDMO for microbial protein production, flexibility, scalability, host diversity, and analytical expertise are key factors to consider.

A strong CDMO tailors its process flow to fit current and future large-scale manufacturing needs. Since microbial processes vary widely, ensuring that a CDMO can effectively implement and scale a process is essential. AGC Biologics offers manufacturing flexibility from 100 L to 4,500 L (3,000 L working volume) with proven commercial expertise, making process transfers seamless and efficient.

Host diversity also plays a critical role, as different cell cultures require unique methods. Evaluating a CDMO’s ability to manage a broad range of processes early in selection helps prevent future challenges. Developers transferring their own cell lines should avoid beta-lactam as a selection marker to mitigate risks associated with allergic reactions. Additionally, a CDMO’s proficiency in analytical method development is crucial for successful recombinant protein production.