LC/MS Method For The Measurement Of Ornithine Carbamoyl Transferase Enzymatic Activity Levels In Human Plasma

Scientists at Aliri Bioanalysis's laboratory in Colorado Springs have successfully developed and validated an innovative enzyme activity assay designed to measure ornithine transcarbamylase (OTC) activity in human plasma. By utilizing the advanced capabilities of mass spectrometry, this assay provides a highly precise and reliable method for assessing OTC activity without the need for invasive tissue biopsies.

This breakthrough offers a significant advancement in the evaluation of OTC function, particularly for individuals with OTC Deficiency. According to the researchers, this plasma-based measurement has the potential to serve as a critical pharmacodynamic biomarker, facilitating the assessment of novel therapeutic approaches for managing OTC Deficiency.