Article | September 28, 2015

Key Advantages Of Jet Milling Including Joule-Thomson Effect During Milling And Micronization

Source: Xcelience, LLC
Key Advantages Of Jet Milling Including Joule-Thomson Effect During Milling And Micronization

By TJ Higley, Vice President, Business Development, Powdersize, with Derek Hennecke, President and CEO, Xcelience

The use of milling and/or micronization with active pharmaceutical ingredients (APIs) to decrease and/or tightly control particle size is a powerful tool to consider during formulation development.  Controlling API particle size, as a critical quality attribute during milling or micronization, provides formulators a cost effective and streamlined means of improving the drug’s aqueous solubility, controlling the dissolution rate and yielding a reproducible dissolution profile within finished dosage form (FDF).