Humanized M-NSG PBMC And CD34+ Mouse Models 2023

Research-ready humanized mouse models are available, generated using M-NSG mice reconstructed with human peripheral blood mononuclear cells (PBMCs) or CD34+ hematopoietic stem cells (HSCs). These models are ideal for infectious disease research, therapeutic development, hematopoiesis studies, drug target validation, and immunogenicity testing. Following injection of healthy human donor PBMCs or CD34+ HSCs, the mice undergo a reconstruction period lasting a few weeks, during which they develop a functional human-like immune system. Once fully reconstituted, the humanized mice are ready for shipment, which offers researchers reliable in vivo models to study human immune responses.

These models provide predictive and translational research tools that facilitate the evaluation of immune interactions with pathogens, drugs, and therapeutic candidates. With convenient, ready-to-use animals possessing established human immune cell populations, these humanized PBMC and CD34+ mouse models help accelerate research timelines and improve the accuracy of preclinical testing in immunology and infectious disease fields.