Hot Melt Extrusion

Hot melt extrusion enables transformation of poorly soluble compounds into amorphous solid dispersions, improving dissolution and bioavailability for challenging drug candidates. Integrated development and manufacturing services support programs from early formulation through commercial production using a structured, stage‑based approach.

Capabilities include API characterization, formulation development, scale‑up modeling, clinical manufacturing, and validated commercial production across multiple global locations. A wide range of extruder sizes and potency handling options support flexible development pathways while accommodating complex molecules. Extensive analytical services, including chromatography, spectroscopy, microscopy, microbiology, and stability testing, reinforce formulation understanding and process control throughout development. Downstream manufacturing options extend into oral solid dose finishing, including milling, tableting, encapsulation, and multiple packaging configurations. Together, these capabilities help reduce development risk, streamline technology transfer, and support reliable commercialization of oral drug products that require advanced strategies to overcome solubility and bioavailability challenges.