Application Note

Formulation of Monodisperse Controlled-Release Quetiapine Microspheres

By Akihisa Nonoyama, Ph.D., Nathan Dormer, Ph.D., and Cory Berkland, Ph.D.

iStock-1214627273-development-lab

ABSTRACT

Objectives

  1. Demonstrate microsphere fabrication capabilities using Optimμm® technology.
  2. Understand the variables to manipulate dissolution profiles of controlled-release microsphere formulations.
  3. Describe how Optimμm technology delivers better particle precision compared to traditional methods.

Methods

Uniform microspheres were fabricated from a proprietary process previously described.1 Briefly, quetiapine was dissolved in melted stearic acid and combined with other excipients (triglycerides, waxes, celluloses, etc). The mixtures were processed through a proprietary nozzle in a single step to produce matrix microspheres in the size range of ~250 μm. Various formulations were dissolution tested in vitro to evaluate controlled release performance.

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