Fast Track Autoradiography

Autoradiography is widely used in CNS studies as it allows for the labeling of receptors and studying cellular uptake and binding sites in brain sections. We have recently upgraded our capabilities in autoradiography for rodents and now offer high-resolution and quantitative autoradiography of beta-emitting radioisotopes. 

With this sensitive autoradiography, data can be acquired in hours for full quantization of the radioligand binding activity, compared to the days or weeks it takes to acquire data when using autoradiography film or storage phosphor screens. When used in combination with in vivo SPECT/CT nuclear imaging, autoradiography can detect the same radioligands and can further facilitate the anatomical localization of signal detection in the ex vivo setting. Fast and sensitive autoradiography is also one of the key tools to support target engagement validation in vivo.

In addition to autoradiography, we offer:

• Tools for studying CNS target engagement with neurobehavioral assessment
• Tailored receptor occupancy assays
• In vivo imaging tools (MRI/MRS/PET/SPECT)
• Ex vivo and in vitro biochemical assays such as histology/immunohistochemistry

To learn more about our models of neurological and psychiatric disease, autoradiography or target engagement, please contact us at askcharlesriver@crl.com.