Extrusion-Based ASD Scale-Up: Ensuring Performance Through Process Understanding

Dive into Hot Melt Extrusion (HME) as a scalable and cost-effective manufacturing technology for ASDs.

Using griseofulvin as a model drug, we present recent experimental data from trials conducted on both lab-scale (5mm) and pilot-scale (18mm) extruders. These studies investigate the critical impact of key process variables—such as melt temperature, residence time, and shear rate—on the final physical state and performance of the dispersion. Gain practical insights into managing these variables effectively during scale-up.

The webinar features a head-to-head comparison of HME and spray drying, highlighting key differences in process control, scalability, and material properties of the resulting dispersions.

Key Learning Objectives

• Understand the fundamental role of ASDs in improving drug bioavailability.
• Discover how Hot Melt Extrusion (HME) is utilized to efficiently manufacture ASDs.
• Identify the process variables (e.g., temperature, shear rate) that most significantly influence ASD quality and scalability.
• Compare and contrast the advantages and limitations of HME and Spray Drying for ASD production.