Essential Insights Into Linker Chemistry For Antibody Drug Conjugates (ADCs)

Antibody-drug conjugates (ADCs) are sophisticated therapies that combine the targeting power of antibodies with the cell-killing efficacy of cytotoxic drugs. At the heart of an ADC’s function is the linker, a specialized chemical tether that is far more than a simple attachment point—it is a critical determinant of the drug's stability, safety, and ultimate efficacy.

Understanding the evolution of linker chemistry is essential for optimizing next-generation ADCs. This field is defined by the move toward greater stability, the strategic use of cleavable versus non-cleavable linkers, and the shift from stochastic to site-specific conjugation methods. Dive into the core challenges of payload release and stability, and see why rigorous developability assessments are crucial for selecting an optimal linker architecture. Read the full article to gain a deeper understanding of the innovative solutions defining this complex and rapidly advancing area of cancer treatment.