Development Of A Franz Cell Permeation Model For Assessment Of Spray Dried Microparticles

Spray drying is a scalable technique for engineering particles designed for targeted delivery. In this study, we demonstrate the capability to manufacture particles of an optimal size for nasal delivery and evaluate their permeation using vertical diffusion cells. These cells were chosen for their low receptor chamber volume, and simulated nasal fluid (SNF) was used to replicate the conditions of the nasal cavity.

This setup also enables the testing of small powder quantities, which is especially important during early-stage development. The use of a dialysis cellulose membrane provided greater differentiation between formulations compared to a regenerated cellulose membrane. Ongoing research is exploring whether formulations containing a poorly water-soluble drug, such as ibuprofen, will show even greater distinction in permeation profiles.