Developing A Novel Approach To Real-Time Monitoring Of Antibody Titer

Optimizing process efficiency is an ongoing goal of the biomanufacturing industry. Improved processes have a direct impact on lowering operating costs, reducing risk of production failures and improving product quality, which all leads to getting drugs to patients efficiently, cost-effectively and in a timely manner. A key step toward achieving this goal is the application of advanced manufacturing methods, such as continuous processing, and the use of automation and data integration to improve operational efficiency and increase flexibility and speed to market.

As the industry continues to apply innovative tools and solutions for manufacturing, it also needs to have real-time monitoring in place that is robust enough to keep up with a modern production suite. In the case of measuring antibody concentration, or “titer,” the current standard method is through offline methods, such as sending samples to quality control labs that take at least 24 hours to return results, or by using the traditional method of high-performance liquid chromatography (HPLC). However, these approaches present challenges to the goal of improved efficiency, leading to the development of a new tool, the Tridex™ from IDEX Health & Science.

In this case study, review how a partnership formed to deliver a solution to HPLC challenges and the best approaches to deliver cost-effective antibody measurements.