Biofluorescent Particle Counters Are Gaining Momentum

Drug filling operations are steadily advancing towards the adoption of biofluorescent particle counters (BFPCs) as a cutting-edge method for environmental monitoring (EM). The 2025 benchmarking report from the BioPhorum Fill Finish workstream, titled “Alternative and Rapid Micro Methods for Biofluorescent Particle Counters (ARMM-BFPC)”, highlights the progress made by 11 companies in integrating this technology, based on data collected from May to December 2024. This report not only outlines the strides taken but also addresses user challenges such as interference testing and validation.

At Cytiva, we are thrilled to see this report published, as it aligns perfectly with our strategic direction. Our approach is shaped by industry trends and the specific needs of our customers who utilize our robotic, gloveless isolators. Michael Miller, PhD, President of Microbiology Consultants, LLC, and a subject matter expert (SME) who has collaborated with Cytiva on the implementation of BFPCs within the SA25 aseptic filling workcell, acknowledges the lengthy journey the industry has undertaken to adopt rapid and alternative microbiological methods. He emphasizes, “Regulators are keen to see these technologies implemented because they enable quicker responses to contamination events. Ultimately, this helps ensure that drug products reach the patients who need them most.”

Read more to discover how partnering with Cytiva can facilitate a smoother transition to BFPC adoption.