Amylin Liver NASH (AMLN)

Animal models of human disease play a critical role in translational research by offering valuable insights into disease mechanisms and enabling the preclinical evaluation of potential therapeutic candidates. These models help bridge the gap between basic research and clinical application, ensuring that treatments are developed on a foundation of biological relevance.

At Aragen, we have developed and validated a diet-induced mouse model that closely replicates key features of human non-alcoholic steatohepatitis (NASH). This model exhibits hallmark characteristics of the human condition, including hepatic steatosis, inflammation, hepatocellular ballooning, and fibrosis, making it a reliable platform for studying disease progression and assessing the efficacy of novel therapeutics targeting NASH.