Adding SYLOID® Mesoporous Silica To Improve Run Time And Yield For Micronization Processes

In this study, Cholesterol was selected as the model active ingredient — a waxy, solid compound that presents considerable processing challenges similar to those encountered with many complex small-molecule APIs. To investigate process enhancement, varying concentrations of SYLOID® mesoporous silica were blended with Cholesterol prior to micronization using a jet mill. This approach enabled a detailed assessment of how mesoporous silica influences both the efficiency and quality of the micronization process.

The results revealed that even low-level additions of SYLOID® mesoporous silica led to notable improvements in run time, yield, and overall process consistency, demonstrating its potential to simplify and strengthen micronization workflows.

Access the full case study to see how small formulation adjustments can lead to substantial performance gains.