Outsourced Pharma App Notes & Case Studies
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Chromatography Solutions For AAV Full And Empty Capsid Separation
3/1/2023
Effective separation of full and empty AAV capsids requires implementation of purification strategies that differ from standard approaches used for traditional modalities. Explore two cases describing such approaches.
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Secondary Packaging Strategies For Commercial Launch Of A Biologic
8/17/2022
A commercial packaging solution can be the first and enduring impression that a sponsor company makes on a patient, and its suitability can impact a biologic’s commercial success.
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Determining RNA Integrity And Purity By Capillary Gel Electrophoresis
6/30/2023
To ensure mRNA product quality, it's important to confirm the integrity of the RNA. Examine the results of a study challenging the performance of the CGE method in assessing mRNA integrity and purity.
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Applying A Platform Approach To Bispecific Antibody Development
6/16/2023
Explore how experts were able to adjust a mAb production and purification platform to be applicable for the rapid development and scale up of a BsAb.
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Generating A Robust Host Cell Line For A Cell Line Development Platform
11/14/2022
Learn how cell performance within the context of the cell line development workflow was confirmed with the successful isolation of stable, high-producing clones from three model monoclonal antibodies.
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Developing A HIC Polishing Step For The Removal Of mAb Aggregates
9/28/2023
Learn in-depth about the development of a flow-through polishing step that employs hydrophobic interaction chromatography for the elimination of monoclonal antibody aggregates.
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Meet An Optimized Suspension-Based Platform Technology
3/5/2024
Discover a ready-to-use, suspension-based platform technology for transient transfection of LVVs that eliminates the need to transition from small-scale adherent processes.
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Alkaline Stability Of Modern Protein A Chromatography Resins
7/12/2023
Explore results from a resin lifetime study with over 150 cycles, using clarified cell harvest in every cycle, which has been performed to evaluate the alkaline stability of three protein A resins.
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Natural Killer Cells Manufacturing
7/22/2022
Follow the feasibility of xeno‑free NK cell expansion, closure of key unit operations, and how future work could focus on fine‑tuning each step to generate a robust, scalable process.
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Accurate HC-LC Pairing And A Close-To-Nature Solution For bsAbs
9/11/2023
Examine how a proprietary technology ensures high levels of accurate HC-LC pairing without detriment to critical quality attributes such as titer, binding affinity, stability, and immunogenicity.