Outsourced Pharma App Notes & Case Studies
-
Impact Of Glycosylation On The Effector Functions Of Monoclonal Antibodies
2/9/2024
In an example using rituximab and its biosimilars, explore the significance of minor differences of glycosylation in antibodies and its impact on their properties and functionality.
-
Optimizing Recovery On The Sepax™ Cell Processing System
7/21/2022
Using a model T-cell line, we demonstrate the impact of varying rinse volume, intermediate volume, and manual extraction parameters on overall cell recovery with a final product dose volume of 20 mL.
-
Biacore™ SPR Systems For Titer Analysis Of Adeno-Associated Virus
10/13/2022
We describe the performance of two assays for titer analysis of adeno-associated virus (AAV), serotype 2 and serotype 5, based on surface plasmon resonance (SPR).
-
Cell Line Development For High-Titer Lentivirus Vector Production
3/21/2024
Explore a groundbreaking method to significantly enhance LV vector yield using engineered HEK293T cells. This approach paves the way for more efficient and large-scale production of LV vectors.
-
Alkaline Stability Of Modern Protein A Chromatography Resins
7/12/2023
Explore results from a resin lifetime study with over 150 cycles, using clarified cell harvest in every cycle, which has been performed to evaluate the alkaline stability of three protein A resins.
-
rAAV Production Using HEK293 Cell Line And Transfection Medium
1/13/2023
Investigate how using a peak expression cell culture medium in the right bioreactor can promote recombinant protein production and improve the performance of a scalable AAV process.
-
Establishing A Robust Workflow To Identify High-Performing Clones
1/13/2023
Cell line development is a complex, labor intensive, and multistep process. Learn about a platform and host cell line that minimize the risk and timeline to develop high-performing clones.
-
Applying A Platform Approach To Bispecific Antibody Development
6/16/2023
Explore how experts were able to adjust a mAb production and purification platform to be applicable for the rapid development and scale up of a BsAb.
-
Recombinant Protein Purification Optimization With HIC
5/1/2023
A step-by-step high-throughput process development (HTPD) workflow to determine the optimal resin and initial conditions for hydrophobic interaction chromatography (HIC).
-
Engineering Approaches To Respiratory Drug Delivery
5/27/2022
Explore the material and performance properties of spray-dried and jet-milled mannitol for respiratory delivery of crystalline mannitol.