Drug Discovery Applications & Studies

  1. A Gene Expression System For Afucosylated Antibody Production 12/4/2023

    Use a gene expression system that allows you to produce molecules that are 100% free of fucose and demonstrate increased potency, without compromising on titers, growth, stability, or product quality.

  2. Laser-Induced Choroidal Neovascularization Model Of Macular Degeneration 4/19/2023

    The laser-induced choroidal neovascularization (CNV) model is an established method to evaluate therapies for wet age-related macular degeneration (wet AMD), a leading cause of blindness in our senior population.

  3. Evaluating Multiple Vectors In A Single Eye 4/18/2023

    Evaluating multiple novel AAV variants can be cost prohibitive. Learn how a new subretinal delivery model enables more responsible use of animal resources and achieves significant cost savings.

  4. How Successful Tech Transfer Can Help Fast-Track NDA Approval 4/4/2023

    Examine the first-time-right tech transfer and phase-3 registration batch manufacturing process which led to a biotech receiving NDA approval for its novel compound followed by a successful commercial manufacturing partnership.

  5. Partnering On An Innovative Hydrogel-Based Treatment For Glioblastoma 3/22/2023

    Treatments for glioblastoma multiforme (GBM) are in high demand. Learn more about the new possibilities for increased dosing and diffusion capabilities offered by nanoformed APIs.

  6. Next Generation Sequencing For Adventitious Agent Detection In Cell Banks 2/23/2023

    NGS-based methods for agnostic broad range detection are suitable options to augment or replace current virus testing methodology. Explore a NGS AAT method for cell line characterization and more.

  7. BEH C18 Batch-To-Batch Robustness For The Analysis Of Rosuvastatin And Impurities 6/30/2022

    The main goal of this study is to investigate the long-term batch-to-batch reproducibility of 10 different lots of XBridge BEH C18 Columns. Discover the findings of this study.

  8. A Phase I Study Allowing Clinical Screening Of Multiple Solubility-Enhancement Formulation Technologies 3/7/2022

    The study was designed to assess the clinical performance of prototype formulations, assess food effect and dose linearity of a selected formulation, and the impact on exposure in subjects taking proton pump inhibitors (PPI).

  9. A Clinical Assessment Of Delayed-Release Coated Capsule Compositions For Regional Gastrointestinal Delivery Using Gamma Scintigraphy 3/7/2022

    Gamma scintigraphy was used to evaluate GI transit and release from 3 capsule prototypes with different coating systems; data on pH, temperature and pressure during GI transit was obtained and correlated.

  10. An Integrated Radiolabelled Study: Determine Mass Balance Metabolite Profile & Absolute Bioavailability 3/3/2022

    The study assessed the absorption and disposition of nolasiban after oral and IV administrations and enabled determination of mass balance, routes and rates of excretion and metabolism and absolute bioavailability.