Overcoming The Raw Material Hurdle: Plasmids For Viral Vector-Based Gene Therapies

Source: Catalent

By Thomas VanCott, Ph.D., Global Head of Product Development, Catalent Cell & Gene Therapy

iStock-1166567390-cell culture

The emerging field of cell and gene therapy is transforming today’s industry by bringing new hope to patients suffering from a wide range of serious and life-threatening diseases. The success of using viral vectors to deliver a molecular payload into a cell or replace defective genes with functional ones is an inflection point in the future of modern medicine. Since the landmark approval of Novartis’ KYMRIAH® in 2017, nearly 20 cell and gene therapies have made it to market.1 Their success, combined with the overall potential of these groundbreaking products has led to expectations by the FDA that the agency will be approving 10 to 20 cell and gene therapy products a year by 2025.2

However, there are several barriers that could delay a commercial upswing for cell and gene therapies, with a key factor being a shortage of critical raw materials. Pharma and biotech companies have converged on CDMOs to fulfill this gap in the market, but with only a limited number possessing the capability and expertise to meet demand, the result is significant capacity constraints and long lead times. Therefore, when evaluating potential partners, choose one that is expanding its offerings and investing in new technology and additional capacity to address market growth, as they will be best suited to support your product now and well into the future.


Get unlimited access to:

Trend and Thought Leadership Articles
Case Studies & White Papers
Extensive Product Database
Members-Only Premium Content
Welcome Back! Please Log In to Continue. X

Enter your credentials below to log in. Not yet a member of Outsourced Pharma? Subscribe today.

Subscribe to Outsourced Pharma X

Please enter your email address and create a password to access the full content, Or log in to your account to continue.


Subscribe to Outsourced Pharma