Medicinal Chemistry
Source: Ricerca Biosciences, LLC
Geared toward the needs of today's biotechnology companies to help further their small-molecule programs, Ricerca's drug discovery services include SAR, focused libraries, custom synthesis, drug-ability assessment, metabolite identification, and impurity studies.
Geared toward the needs of today's biotechnology companies to help further their small-molecule programs, Ricerca's drug discovery services include SAR, focused libraries, custom synthesis, drug-ability assessment, metabolite identification, and impurity studies. Ricerca scientists will work with your team to advance your drug discovery programs from hit molecules to the next development candidate for an IND.
Drug discovery services
- Medicinal chemistry
- Structure-Activity Relationship (SAR) lead optimization
- Drug-ability assessment studies, including integrated discovery chemistry and biology services
- Focused library synthesis, with parallel capabilities
- Custom synthesis of APIs ranging from milligram to multiple hundred grams of biologically active compounds
- Preclinical development support
- Metabolite and impurity identification
- Metabolite and impurity synthesis
- Structure identification and characterization
Capabilities
- LC-MS, LC-MS/MS (analytical and prep)
- HPLC (analytical and prep)
- IR; UV; DSC; TGA; Polarimetry
- NMR 300 MHz and 400 MHz (1H, 13C, 19F, 31P, COSY, NOESY, ROESY, HMBC, HMQC)
- Parallel reactors
- Speed vac
- Automated flash purification (mg to g)
- Small-molecule x-ray crystallography
- Microwave reactor