Poster

Accelerating Antibody Drug Development With Subdomain-Specific Affinity Ligands

By Pim Hermans, Frank Detmers, Kevin Sleijpen, Simon Adema, Hendrik Adams, Elina Klijs, Anja Overweel, Paul Janszen and Jessica de Rooij

With the development of novel bio-therapeutic antibody formats, such as trifunctional and bispecific monoclonal antibodies or antibody fragments, new purification challenges in the downstream process of these molecules arise.

Thermo Scientific™ CaptureSelect™ antibody subdomain-specific affinity products and analytical tools are developed for the discovery and manufacturing of therapeutic antibodies and antibody fragments. The affinity resins provide high target purity in a single step, independent of feedstock.

CAPTURE SELECT TECHNOLOGY – UNIQUE AFFINITY PURIFICATION SOLUTION

  • Affinity through antibody selectivity: technology based on Camelidsingle domain [VHH] antibody fragments
  • Unique VHH screening technology to determine final resin properties such as target specificity, mild elution & ligand stability
  • Animal origin free production process (Saccharomyces Cerevisiae)
  • Technology used in commercial purification processes

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